Cyclobenzaprine Flexeril: Dosage & Side Effects

When certain drugs are used with cyclobenzaprine, they may cause more severe side effects such as increased drowsiness or sedation. A person should ask their doctor whether it is safe to combine another medication with cyclobenzaprine and take care not to operate any machinery while taking it. Abuse of muscle relaxants alone is uncommon; often, it involves other substances. This document does not contain all possible interactions.

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So, please don’t discount the need for professional treatment if you’re addicted to Flexeril. If you attempt to quit using it on your own, you put yourself at risk for an overdose. There is also the possibility of becoming psychologically dependent on Flexeril because of the feelings of relaxation. Flexeril on its own may not be as susceptible to creating addiction but when it’s abused, there’s a much greater risk. And when cyclobenzaprine and alcohol, opioids, or drugs are used in combination, that risk becomes even higher. People will abuse cyclobenzaprine to enhance the effects of alcohol or mind-altering drugs.

Can You Overdose on Cyclobenzaprine (Flexeril)?

Drowsiness and confusion can increase the risk of falling. Call your doctor or local poison control center immediately if you have an allergic reaction. Call 911 or go to the nearest emergency room if your symptoms are severe.

Cyclobenzaprine caused slight to moderate increase in heart rate in animals. For most patients, the recommended dose of FLEXERIL is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of FLEXERIL for periods longer than two or three weeks is not recommended.

When used alone, alcohol can end up slowing respiration to deadly levels due to alcohol poisoning. Flexeril abuse can also end up leading to dangerously slow respiration. When Flexeril and alcohol are mixed, however, these qualities can actually end up overlapping, making the potentially fatal risk of low respiration even more likely to occur.

Cyclobenzaprine is a skeletal muscle relaxant that works by increasing the release of the chemical norepinephrine from central nervous structures in the brain, Patel said. Cyclobenzaprine is not designed for long-term use, and patients should follow the regimen provided by their physician, said Dr. Kiran Patel, pain management specialist at Lenox Hill Hospital. “It’s a muscle relaxant that can help with a muscle flexeril brand name discontinued spam or the sensation of tightness,” Patel told Live Science. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Cyclobenzaprine is structurally and pharmacologically related to tricyclic antidepressants. Among the most dreaded toxicities linked with cyclical antidepressants, overdoses affect fast-acting sodium channels in the cardiac conduction system.

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FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Make your tax-deductible gift and be a part of the cutting-edge research and care that’s changing medicine. You’ll soon start receiving the latest Mayo Clinic health information you requested in your inbox.

Effect of VLD CBP on macrostructure of sleep EEG

Cyclical antidepressants block the cardiac sodium channel and cause prolongation of cardiac depolarization, which manifests as QRS widening on electrocardiograms. There is also evidence that cyclical antidepressants may decrease the seizure threshold by interfering with chloride conductance on the GABA receptor. Correlation of increased nights of CAPA2+A3(Norm) ≤ 33% with VLD CBP improvements on FM symptoms and sleep EEG measures.

• Call your doctor if your symptoms do not improve after 3 weeks, or if they get worse.
• Laboratory tests with values that became clinically significantly abnormal after drug administration were repeated until the values returned to normal or the etiology was identified and the sponsor notified.
• Some skeletal muscle relaxants (e.g., carisoprodol) have sedative properties so people may attempt to misuse a drug like cyclobenzaprine thinking that it will have similar sedating effects.
• To do so may increase the chance of serious side effects.
• Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Investigators were allowed to adjust dosage throughout the study as tolerability allowed. Daily dose ranged from 2 to 4 mg in the VLD CBP group at Week 8, with a group mean of 3.1 mg. Placebo capsules were titrated to a dose corresponding to 2.1 mg.

These drugs are often used to treat similar conditions. Many treatment programs offer medical detoxification to address physical dependence in a safe environment with caring physicians and nurses who will work to alleviate symptoms and increase your comfort. There are options available across the full continuum of care to help with substance abuse. Take this medication by mouth with or without food as directed by your doctor, usually once daily. Doing so can release all of the drugs at once, increasing the risk of side effects.